Pseudouridines in rRNA helix 69 play a role in loop stacking interactions

Org Biomol Chem. 2008 Nov 7;6(21):3892-5. doi: 10.1039/b812731j. Epub 2008 Sep 19.

Abstract

The (1)H NMR spectra of RNAs representing E. coli 23S rRNA helix 69 with [1,3-(15)N]pseudouridine modification at specific sites reveal unique roles for pseudouridine in stabilizing base-stacking interactions in the hairpin loop region.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Base Pairing
  • Base Sequence
  • Inverted Repeat Sequences / genetics
  • Nucleic Acid Conformation*
  • Protons
  • Pseudouridine / chemistry*
  • Pseudouridine / genetics
  • RNA, Ribosomal, 23S / chemistry*
  • RNA, Ribosomal, 23S / genetics

Substances

  • Protons
  • RNA, Ribosomal, 23S
  • Pseudouridine