Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp

Mini Rev Med Chem. 2008 Oct;8(12):1203-8. doi: 10.2174/138955708786141089.

Abstract

Collinin is a geranyloxycoumarins isolated in small amounts from plants of the Rutaceae family. Synthetic schemes were recently developed allowing to handle collinin in sufficient quantities to put in evidence valuable biological effects. The aim of this review is to examine the phytochemical and pharmacological properties of this compound.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / pharmacology
  • Chemistry, Pharmaceutical / methods
  • Coumarins / analysis
  • Coumarins / chemistry*
  • Drug Design
  • Humans
  • Mice
  • Mice, Inbred ICR
  • Models, Chemical
  • Phytotherapy
  • Plant Extracts / analysis
  • Plant Extracts / chemistry*
  • Rabbits
  • Zanthoxylum / metabolism*

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Coumarins
  • Plant Extracts
  • collinin