Abstract
G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / toxicity
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Base Sequence
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DNA / chemistry
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DNA / genetics
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DNA / metabolism
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Drug Design*
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G-Quadruplexes / drug effects*
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Humans
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Ligands
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Substrate Specificity
Substances
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Antineoplastic Agents
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Ligands
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DNA