Abstract
The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Anthrax / drug therapy
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Anti-HIV Agents / pharmacology
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Anti-HIV Agents / therapeutic use
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Cardiovascular Diseases / drug therapy
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Cardiovascular Diseases / genetics
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Computational Biology / methods*
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Drug Design*
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Forecasting
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HIV-1 / drug effects
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Humans
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Influenza A Virus, H5N1 Subtype / drug effects
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Influenza A Virus, H5N1 Subtype / isolation & purification
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Molecular Sequence Data
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Mutation
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Proteins / chemistry*
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Proteins / metabolism
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Risk Factors
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Structure-Activity Relationship