Abstract
An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Amino Alcohols / chemical synthesis*
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Amino Alcohols / chemistry
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Butanols / chemistry*
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Free Radicals / chemistry
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Hydroxylation
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Imines / chemistry*
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Methylation
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Molecular Structure
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Thallium / chemistry*
Substances
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Aldehydes
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Amino Alcohols
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Butanols
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Free Radicals
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Imines
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thallium chloride
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Thallium