Efficient coding in heterogeneous neuronal populations

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16344-9. doi: 10.1073/pnas.0807744105. Epub 2008 Oct 14.

Abstract

A ubiquitous feature of neuronal responses within a cortical area is their high degree of inhomogeneity. Even cells within the same functional column are known to have highly heterogeneous response properties when the same stimulus is presented. Whether the wide diversity of neuronal responses is an epiphenomenon or plays a role for cortical function is unknown. Here, we examined the relationship between the heterogeneity of neuronal responses and population coding. Contrary to our expectation, we found that the high variability of intrinsic response properties of individual cells changes the structure of neuronal correlations to improve the information encoded in the population activity. Thus, the heterogeneity of neuronal responses is in fact beneficial for sensory coding when stimuli are decoded from the population response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Models, Neurological
  • Neurons / physiology*
  • Psychophysiology
  • Visual Perception