Abstract
The synthesis and the biological (antioxidant and antiviral) activities of novel hydroxycinnamic acid amides of a thiazole containing TFA.valine-4-carboxylic acid ethyl ester are reported. The amides have been synthesized from p-coumaric, ferulic and sinapic acids with the corresponding TFA.valine-thiazole-4-carboxylic acid ethyl ester using the coupling reagent N-ethyl-N'-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and 4-(dimethylamino) pyridine (DMAP) as a catalyst. The antioxidant properties of the newly synthesized amides have been studied for then antioxidative activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH)* test. The newly synthesized compounds have been tested against the replication in vitro of influenza virus A (H3N2) and human herpes virus 1 and 2 (HSV-1 and HSV-2).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Animals
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Antioxidants* / chemical synthesis
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Antioxidants* / chemistry
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Antioxidants* / metabolism
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Antiviral Agents* / chemical synthesis
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Antiviral Agents* / chemistry
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Antiviral Agents* / metabolism
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Biphenyl Compounds / metabolism
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Cell Line
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Coumaric Acids* / chemical synthesis
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Coumaric Acids* / chemistry
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Coumaric Acids* / metabolism
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Free Radical Scavengers / metabolism
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Free Radicals / metabolism
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Herpesvirus 1, Human / physiology
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Herpesvirus 2, Human / physiology
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Humans
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Mice
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Molecular Structure
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Picrates / metabolism
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Thiazoles / chemistry*
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Virus Replication
Substances
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Amino Acids
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Antioxidants
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Antiviral Agents
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Biphenyl Compounds
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Coumaric Acids
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Free Radical Scavengers
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Free Radicals
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Picrates
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Thiazoles
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1,1-diphenyl-2-picrylhydrazyl