Efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis in vitro and in an experimental model of actinomycetoma in BALB/c mice

Antimicrob Agents Chemother. 2009 Jan;53(1):295-7. doi: 10.1128/AAC.01023-08. Epub 2008 Oct 13.

Abstract

The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis. A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aza Compounds / pharmacology*
  • Ciprofloxacin / pharmacology*
  • Disease Models, Animal
  • Female
  • Fluoroquinolones
  • Mice
  • Mice, Inbred BALB C
  • Microbial Sensitivity Tests
  • Moxifloxacin
  • Mycetoma / drug therapy*
  • Mycetoma / microbiology*
  • Nocardia / drug effects*
  • Nocardia / pathogenicity*
  • Quinolines / pharmacology*

Substances

  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Ciprofloxacin
  • Moxifloxacin