Retinal pigment epithelial marginal retraction after photodynamic therapy for choroidal neovascularization in pathologic myopia

Eur J Ophthalmol. 2008 Sep-Oct;18(5):841-4. doi: 10.1177/112067210801800533.

Abstract

Purpose: To report the incidence of retinal pigment epithelial (RPE) marginal retraction after verteporfin photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV) in pathologic myopia (PM).

Methods: Retrospective review of 236 patients treated with PDT for subfoveal CNV due to PM.

Results: RPE marginal retraction was found in 3 eyes (1.3%), and a decrease of a mean of five lines of vision was reported to occur 10-15 days after treatment. At the end of followup two eyes lost three lines and one six lines from baseline.

Conclusions: RPE marginal retraction as an early complication of PDT for subfoveal CNV secondary to PM is rare. The low incidence of this adverse event, however, should not preclude recommendations for PDT in myopic eyes that could benefit from this treatment modality.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / drug therapy*
  • Choroidal Neovascularization / etiology
  • Fluorescein Angiography
  • Humans
  • Male
  • Middle Aged
  • Myopia, Degenerative / complications*
  • Photochemotherapy / adverse effects*
  • Photosensitizing Agents / adverse effects
  • Pigment Epithelium of Eye / drug effects*
  • Porphyrins / adverse effects
  • Retinal Diseases / chemically induced*
  • Verteporfin
  • Visual Acuity

Substances

  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin