A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum

Takeshi Itabashi; Tomoo Hosoe; Daigo Wakana; Kazutaka Fukushima; Kayoko Takizawa; Takashi Yaguchi; Kaoru Okada; Galba Maria de Campos Takaki; Ken-ichi Kawai

doi:10.1007/s11418-008-0292-6

A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum

J Nat Med. 2009 Jan;63(1):96-9. doi: 10.1007/s11418-008-0292-6. Epub 2008 Oct 11.

Authors

Takeshi Itabashi¹, Tomoo Hosoe, Daigo Wakana, Kazutaka Fukushima, Kayoko Takizawa, Takashi Yaguchi, Kaoru Okada, Galba Maria de Campos Takaki, Ken-ichi Kawai

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.

PMID: 18850072
DOI: 10.1007/s11418-008-0292-6

Abstract

In a screen searching for new bioactive agents, a new indoloditerpene, penijanthine A (1), was isolated from Penicillium janthinellum IFM 55557. The structure of 1 was established on the basis of spectroscopic and chemical investigation, as well as detailed comparison with the spectroscopic and physico-chemical data of paxilline (2), which was isolated along with 1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology
Aspergillus fumigatus / drug effects
Diterpenes / chemistry*
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Indoles / chemistry*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Penicillium / chemistry*

Substances

Antifungal Agents
Diterpenes
Indoles
penijanthine A