Abstract
Bioassay-guided fractionation of a root extract of Sorocea muriculata led to the isolation and identification of two new oxygen heterocyclic Diels-Alder-type adducts, sorocenols G (1) and H (2), along with lupeol-3-(3' R-hydroxytetradecanoate) and oxyresveratrol. The structures of 1 and 2 were elucidated using 1D and 2D NMR spectroscopic and HRMS data and by comparison with reported values. The absolute configurations of 1 and 2 were established by analysis of their experimental and theoretically calculated CD spectra. Compounds 1 and 2 showed significant and selective activity against methicillin-resistant Staphylococcus aureus with IC50 values of 1.5 and 0.5 microM, respectively. Compound 2 also displayed antifungal activity against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, with IC 50 values of 5.4, 5.4, and 10.0 microM, respectively.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / isolation & purification
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Anti-Bacterial Agents* / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Aspergillus fumigatus / drug effects
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Benzofurans / chemistry*
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Benzofurans / isolation & purification*
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Inhibitory Concentration 50
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Methicillin Resistance / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Moraceae / chemistry*
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Oxygen / chemistry
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Peru
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Roots / chemistry
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Staphylococcus aureus / drug effects*
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Stilbenes / chemistry
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Stilbenes / isolation & purification
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Benzofurans
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Plant Extracts
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Stilbenes
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sorocenol G
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sorocenol H
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puag-haad
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Oxygen