Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity

ChemMedChem. 2008 Nov;3(11):1649-53. doi: 10.1002/cmdc.200800172.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Chemistry, Pharmaceutical / methods
  • Chloroquine / chemistry*
  • Chloroquine / pharmacology
  • Drug Design
  • Hemeproteins / antagonists & inhibitors*
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Models, Biological
  • Models, Chemical
  • Molecular Structure
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / metabolism*
  • Structure-Activity Relationship

Substances

  • Antimalarials
  • Hemeproteins
  • Pyrimidines
  • hemozoin
  • Chloroquine