Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?

F Kaya; S Belin; Gr Diamantidis; M Fontes

doi:10.1016/j.febslet.2008.09.040

Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?

FEBS Lett. 2008 Oct 29;582(25-26):3614-8. doi: 10.1016/j.febslet.2008.09.040. Epub 2008 Oct 1.

Authors

F Kaya¹, S Belin, Gr Diamantidis, M Fontes

Affiliation

¹ INSERM UMR EA4263, Medical Genetics, Faculté de Médecine de la Timone, 13385 Marseille cedex 5, France.

PMID: 18835269
DOI: 10.1016/j.febslet.2008.09.040

Abstract

Recently, using an animal model of Charcot-Marie-Tooth human disorder, we showed that ascorbic acid (AA) represses PMP22 gene expression by acting on intracellular cAMP concentrations. In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenylyl Cyclase Inhibitors*
Adenylyl Cyclases / genetics
Animals
Ascorbic Acid / pharmacology*
Ascorbic Acid / physiology
Cell Line
Cyclic AMP / antagonists & inhibitors*
Cyclic AMP / biosynthesis
Enzyme Inhibitors / pharmacology*
Gene Expression / drug effects
Isoenzymes / antagonists & inhibitors
Isoenzymes / genetics
Kinetics
Mice

Substances

Adenylyl Cyclase Inhibitors
Enzyme Inhibitors
Isoenzymes
Cyclic AMP
Adenylyl Cyclases
Ascorbic Acid