Abstract
A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology*
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Carcinoma, Hepatocellular / genetics
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Carcinoma, Hepatocellular / virology
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Cell Proliferation / drug effects
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Furans / chemical synthesis
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Furans / pharmacology*
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Genome, Viral*
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Hepacivirus / drug effects*
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Hepacivirus / genetics
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Hepatitis C / drug therapy
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Hepatitis C / virology
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Humans
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Liver Neoplasms / genetics
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Liver Neoplasms / virology*
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Molecular Structure
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RNA, Viral / genetics*
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Replicon / drug effects*
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Tumor Cells, Cultured
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Viral Nonstructural Proteins / genetics
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Virus Replication / drug effects*
Substances
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2,5-dihydro-2-methyl-4-(methylamino)-5-oxo-N-phenylfuran-3-carboxamide
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Antiviral Agents
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Furans
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NS3 protein, hepatitis C virus
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RNA, Viral
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Viral Nonstructural Proteins