Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines

Dimby Andrianina Ralambomanana; Dorothée Razafimahefa-Ramilison; Andry Clément Rakotohova; Jeanne Maugein; Lydie Pélinski

doi:10.1016/j.bmc.2008.09.030

Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines

Bioorg Med Chem. 2008 Nov 1;16(21):9546-53. doi: 10.1016/j.bmc.2008.09.030. Epub 2008 Sep 13.

Authors

Dimby Andrianina Ralambomanana¹, Dorothée Razafimahefa-Ramilison, Andry Clément Rakotohova, Jeanne Maugein, Lydie Pélinski

Affiliation

¹ Université des Sciences et Technologie de Lille, Unité de Catalyse et de Chimie du Solide, UMR CNRS 8181, ENSCL, B.P. 108, 59652 Villeneuve d'Ascq, France.

PMID: 18835177
DOI: 10.1016/j.bmc.2008.09.030

Abstract

A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exhibit better activities than ferrocenyl diaminoalcohols.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Alcohols / chemical synthesis
Amino Alcohols / chemistry
Amino Alcohols / pharmacology
Antitubercular Agents / chemical synthesis*
Antitubercular Agents / pharmacology*
Diamines / chemical synthesis
Diamines / chemistry
Diamines / pharmacology
Ferrous Compounds / chemical synthesis*
Ferrous Compounds / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Structure-Activity Relationship

Substances

Amino Alcohols
Antitubercular Agents
Diamines
Ferrous Compounds