Synthesis of beta-, gamma-, and delta-lactams via Pd(II)-catalyzed C-H activation reactions

J Am Chem Soc. 2008 Oct 29;130(43):14058-9. doi: 10.1021/ja807129e. Epub 2008 Oct 4.

Abstract

Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acetates / chemistry
  • Catalysis
  • Copper / chemistry
  • Lactams / chemical synthesis*
  • Lactams / chemistry
  • Molecular Structure
  • Palladium / chemistry*
  • Silver Compounds / chemistry
  • Stereoisomerism

Substances

  • Acetates
  • Lactams
  • Silver Compounds
  • silver acetate
  • Palladium
  • Copper
  • cupric chloride