Abstract
Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acetates / chemistry
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Catalysis
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Copper / chemistry
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Lactams / chemical synthesis*
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Lactams / chemistry
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Molecular Structure
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Palladium / chemistry*
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Silver Compounds / chemistry
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Stereoisomerism
Substances
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Acetates
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Lactams
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Silver Compounds
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silver acetate
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Palladium
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Copper
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cupric chloride