Abstract
Antibody and T-cell reactivities to Plasmodium vivax merozoite surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. The antibody responses to PvMSP9-RIRIIand PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgG1 was the predominant isotype for PvMSP9-Nt and PvMSP9-RIRII in Ribeirinha. IFN-gamma and IL-4 predominated in Ribeirinha, while IFN-gamma predominated in Colina. Variation in exposure to P. vivax likely accounts for the differences observed in cytokine and antibody levels between the two populations studied.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Antibodies, Protozoan / blood
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Antibodies, Protozoan / immunology*
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Antibody Formation / immunology
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Brazil / epidemiology
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Cohort Studies
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Cross-Sectional Studies
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Epitopes, T-Lymphocyte / immunology
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Female
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Humans
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Immunity, Active
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Immunity, Cellular
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Immunoglobulin G / blood
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Immunoglobulin G / immunology
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Interferon-gamma / blood
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Interferon-gamma / immunology
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Interleukin-4 / blood
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Interleukin-4 / immunology
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Malaria, Vivax / epidemiology
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Malaria, Vivax / immunology*
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Male
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Membrane Proteins / immunology*
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Middle Aged
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Plasmodium vivax / immunology*
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Prevalence
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Protozoan Proteins / immunology*
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Recombinant Proteins / immunology
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Young Adult
Substances
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Antibodies, Protozoan
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Epitopes, T-Lymphocyte
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Immunoglobulin G
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Membrane Proteins
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Protozoan Proteins
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Recombinant Proteins
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merozoite surface protein 9, Plasmodium
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Interleukin-4
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Interferon-gamma