Deterministic dynamics in neuronal discharge from pallidotomy targets

J Int Med Res. 2008 Sep-Oct;36(5):979-85. doi: 10.1177/147323000803600514.

Abstract

The non-linear dynamic specificity of the firing pattern discharged from neurons of the internal globus pallidus (GPi) was investigated by recording their spontaneous firing using a microelectrode during posteroventral pallidotomy in eight patients with Parkinson's disease. Raw data from the cells were processed to extract spiking events (discharges above a selected threshold) and the interspike interval was measured. Using the unstable periodic orbits extraction method, significant period-1, -2 and -3 orbits were identified in burst firing discharged from the GPi cells in all eight patients, suggesting that deterministic dynamics exist in the timing of the discharges. As well as providing a useful peri-operative technique for locating posteroventral pallidotomy targets in Parkinson's disease, this method also provides a promising basis for investigating characteristic neuronal discharges in other regions of the brain and for various other neurological disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Aged
  • Female
  • Globus Pallidus* / cytology
  • Globus Pallidus* / physiology
  • Humans
  • Male
  • Microelectrodes
  • Middle Aged
  • Neurons / physiology*
  • Pallidotomy*
  • Parkinson Disease / physiopathology
  • Parkinson Disease / surgery