Microgravimetric lectin biosensor based on signal amplification using carbohydrate-stabilized gold nanoparticles

Chem Commun (Camb). 2008 Oct 21:(39):4771-3. doi: 10.1039/b807438k. Epub 2008 Aug 4.

Abstract

A highly sensitive microgravimetric lectin biosensor has been developed using carbohydrate-stabilized Au nanoparticles as a signal amplifier; mannose-stabilized Au nanoparticles formed a sandwich-type complex with the target Con A specifically bound to a mannose-modified Au QCM electrode to give an amplified frequency response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques* / instrumentation
  • Biosensing Techniques* / methods
  • Carbohydrates / chemistry*
  • Concanavalin A / analysis*
  • Electrodes
  • Gold / chemistry*
  • Mannose / chemistry
  • Metal Nanoparticles / chemistry*
  • Particle Size
  • Sensitivity and Specificity
  • Surface Properties
  • Time Factors

Substances

  • Carbohydrates
  • Concanavalin A
  • Gold
  • Mannose