Abstract
VP30 is a phosphoprotein essential for the initiation of Ebola virus transcription. In this work, we have studied the effect of mutations in VP30 phosphorylation sites on the ebolavirus replication cycle by using a reverse genetics system. We demonstrate that VP30 is involved in reinitiation of gene transcription and that this activity is affected by mutations at the phosphorylation sites.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Cricetinae
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Ebolavirus / genetics
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Ebolavirus / metabolism*
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Mutation / genetics
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Transcription, Genetic / genetics*
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Viral Proteins / genetics
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Viral Proteins / metabolism*
Substances
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Recombinant Proteins
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Transcription Factors
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VP30 protein, ebola virus
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Viral Proteins