Abstract
A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1H-imidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Capsules
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Chromatography, Liquid / methods
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Dietary Supplements / analysis*
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Drug Contamination*
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Erectile Dysfunction / diet therapy*
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Humans
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Imidazoles / chemistry*
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Imidazoles / isolation & purification
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Magnetic Resonance Spectroscopy / methods
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Male
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Mass Spectrometry / methods
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Molecular Structure
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Phosphodiesterase Inhibitors / chemistry*
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Phosphodiesterase Inhibitors / isolation & purification
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Quinazolines / chemistry*
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Quinazolines / isolation & purification
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Spectrophotometry, Ultraviolet / methods
Substances
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Capsules
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Imidazoles
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Phosphodiesterase Inhibitors
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Quinazolines
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KF 31327