Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement

J Pharm Biomed Anal. 2008 Dec 1;48(4):1070-5. doi: 10.1016/j.jpba.2008.08.019. Epub 2008 Aug 23.

Abstract

A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1H-imidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsules
  • Chromatography, Liquid / methods
  • Dietary Supplements / analysis*
  • Drug Contamination*
  • Erectile Dysfunction / diet therapy*
  • Humans
  • Imidazoles / chemistry*
  • Imidazoles / isolation & purification
  • Magnetic Resonance Spectroscopy / methods
  • Male
  • Mass Spectrometry / methods
  • Molecular Structure
  • Phosphodiesterase Inhibitors / chemistry*
  • Phosphodiesterase Inhibitors / isolation & purification
  • Quinazolines / chemistry*
  • Quinazolines / isolation & purification
  • Spectrophotometry, Ultraviolet / methods

Substances

  • Capsules
  • Imidazoles
  • Phosphodiesterase Inhibitors
  • Quinazolines
  • KF 31327