Abstract
The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its signaling functions.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Eukaryotic Cells / chemistry
-
Eukaryotic Cells / metabolism*
-
Humans
-
Protein Interaction Mapping
-
Telomere / chemistry
-
Telomere / metabolism*
-
Telomere-Binding Proteins / chemistry
-
Telomere-Binding Proteins / metabolism*
Substances
-
Telomere-Binding Proteins