Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B(4), B(5), C(1), and D(1)-D(3)

Chem Pharm Bull (Tokyo). 2008 Oct;56(10):1438-44. doi: 10.1248/cpb.56.1438.

Abstract

From the methanolic extract of the whole plant of Sinocrassula indica (Crassulaceae), six new flavonol glycosides, sinocrassosides B(4) (1), B(5) (2), C(1) (3), D(1) (4), D(2) (5), and D(3) (6), were isolated together with 30 compounds. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. In addition, several constituents were found to show inhibitory effects on aminopeptidase N and aldose reductase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors*
  • Animals
  • CD13 Antigens / antagonists & inhibitors*
  • Cell Line, Tumor
  • Crassulaceae / chemistry*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Flavones / chemical synthesis*
  • Flavones / pharmacology*
  • Glycosides / chemical synthesis*
  • Glycosides / pharmacology*
  • Humans
  • Lens, Crystalline / drug effects
  • Lens, Crystalline / enzymology
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / pharmacology*
  • Rats
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Enzyme Inhibitors
  • Flavones
  • Glycosides
  • Protease Inhibitors
  • Aldehyde Reductase
  • CD13 Antigens