Objective: To investigate the effect of polysaccharides in crude and processed Cornus officinalis on the immunologic function of mice with immunosuppression induced.
Methods: The immunosuppressed mice were induced by Cyclophosphamide. Non-specific immune function was determined by cleaning carbon particle method. Humoral immunity was determined by serum haemolysin formation method. Cellular immunity was determined by proliferation and transformation of spleen lymphocyte method.
Results: The polysaccharides in crude and processed Cornus officinalis both markedly increased the carbon particle clearance index K, phagocytic index alpha, serum HC50 and proliferation and transformation of spleen lymphocyte,and the polysaccharides in processed Cornus officinalis was better than the crude one.
Conclusion: The polysaccharides in crude and processed Cornus officinalis have an enhanced effect on non-specific immunity, specific humoral immunity and specific cellular immunity in immunodeppressed mice, and after being processed with wine, the action of polysaccharides increased markedly.