Abstract
Ten novel compounds were designed and synthesized on the basis of compound 1, their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Results showed that compound 10 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, which indicated that compound 10 may possess well insulin-sensitizing activity.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Animals
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Benzopyrans / chemical synthesis*
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Benzopyrans / pharmacology
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Drug Design
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / pharmacology
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Insulin / pharmacology*
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Mice
Substances
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Benzopyrans
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Hypoglycemic Agents
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Insulin