[Design and synthesis of a type of benzopyran derivatives with insulin-sensitizing activity]

Yao Xue Xue Bao. 2008 Jun;43(6):605-10.
[Article in Chinese]

Abstract

Ten novel compounds were designed and synthesized on the basis of compound 1, their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Results showed that compound 10 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, which indicated that compound 10 may possess well insulin-sensitizing activity.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Animals
  • Benzopyrans / chemical synthesis*
  • Benzopyrans / pharmacology
  • Drug Design
  • Hypoglycemic Agents / chemical synthesis*
  • Hypoglycemic Agents / pharmacology
  • Insulin / pharmacology*
  • Mice

Substances

  • Benzopyrans
  • Hypoglycemic Agents
  • Insulin