Syntheses of the tedanolides

Nat Prod Rep. 2008 Oct;25(5):862-70. doi: 10.1039/b719607e. Epub 2008 Apr 25.

Abstract

This Highlight covers the synthetic contributions leading to the syntheses of tedanolide and 13-deoxytedanolide or the corresponding macrolactones, respectively. Additionally, the first SAR data for 13-deoxytedanolide (published by Fusetani) are presented.

Publication types

  • Review

MeSH terms

  • Animals
  • Macrolides / chemical synthesis*
  • Macrolides / chemistry
  • Molecular Structure
  • Polyketide Synthases / metabolism
  • Porifera / chemistry
  • Structure-Activity Relationship

Substances

  • 13-deoxytedanolide
  • Macrolides
  • Polyketide Synthases
  • tedanolide