Questioning the role of rebound firing in the cerebellum

Nat Neurosci. 2008 Nov;11(11):1256-8. doi: 10.1038/nn.2195. Epub 2008 Sep 28.

Abstract

A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology*
  • Action Potentials / radiation effects
  • Animals
  • Animals, Newborn
  • Cerebellar Nuclei / cytology*
  • Electric Stimulation / methods
  • In Vitro Techniques
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Models, Neurological*
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Neural Inhibition / radiation effects
  • Neurons / classification
  • Neurons / drug effects
  • Neurons / physiology*
  • Neurons / radiation effects
  • Patch-Clamp Techniques
  • Rats
  • Rats, Wistar
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • gamma-Aminobutyric Acid