Abstract
Eleven new meroditerpenoids (7-11, 14-17, 19, 20) and nine known compounds (1-6, 12, 13, 18) were isolated from the brown alga Sargassum siliquastrum. Combined chemical and spectroscopic analyses revealed a common tetraprenyl hydroquinone structure; these compounds belonged to the nahocol, isonahocol, and sargahydroquinoic acid classes. The dihydroquinone moiety of 20 was unique and unprecedented in a brown alga. Stereochemical assignments were made for several of the known compounds based on their chemical reactivity. These compounds exhibited moderate to significant radical-scavenging activity as well as weak inhibitory activities against sortase A and isocitrate lyase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoacyltransferases / antagonists & inhibitors
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Bacterial Proteins / antagonists & inhibitors
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Candida albicans / enzymology
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Cysteine Endopeptidases
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Diterpenes / chemistry*
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Free Radical Scavengers / chemistry*
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Isocitrate Lyase / antagonists & inhibitors
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Korea
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Microbial Sensitivity Tests
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Molecular Structure
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Sargassum / chemistry*
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Staphylococcus aureus / enzymology
Substances
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Bacterial Proteins
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Benzopyrans
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Diterpenes
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Free Radical Scavengers
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Aminoacyltransferases
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sortase A
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Cysteine Endopeptidases
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Isocitrate Lyase