Manipulating replication processes within a dynamic covalent framework

Vicente del Amo; Alexandra M Z Slawin; Douglas Philp

doi:10.1021/ol8018665

Manipulating replication processes within a dynamic covalent framework

Org Lett. 2008 Oct 16;10(20):4589-92. doi: 10.1021/ol8018665. Epub 2008 Sep 25.

Authors

Vicente del Amo¹, Alexandra M Z Slawin, Douglas Philp

Affiliation

¹ EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, United Kingdom.

PMID: 18816121
DOI: 10.1021/ol8018665

Abstract

The reaction of an amine bearing an amidopyridine recognition site and an aldehyde bearing a carboxylic acid recognition site affords an imine that is capable of directing its own formation through a dynamic covalent replication cycle. Additionally, the amine, formed by reduction of the replicating imine, is a more efficient catalyst for the formation of the replicating imine than the imine is a catalyst for its own formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Models, Chemical*
Models, Molecular
Molecular Structure
X-Ray Diffraction