Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand

Chem Commun (Camb). 2008 Oct 14:(38):4564-6. doi: 10.1039/b807916a. Epub 2008 Aug 4.

Abstract

Two new bis(benzimidazole)aryl derivatives have been prepared and one of them has been shown to induce and stabilize formation of a G-quadruplex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Benzimidazoles / chemical synthesis
  • Benzimidazoles / chemistry*
  • Benzimidazoles / pharmacology*
  • DNA / chemistry
  • DNA / genetics
  • G-Quadruplexes / drug effects*
  • Ligands
  • Pyridines / chemical synthesis
  • Pyridines / chemistry*
  • Pyridines / pharmacology*

Substances

  • 2,6-bis(benzimidazol-2-yl)pyridine
  • Benzimidazoles
  • Ligands
  • Pyridines
  • DNA