Anxiety and cognitive efficiency: differential modulation of transient and sustained neural activity during a working memory task

Cogn Affect Behav Neurosci. 2008 Sep;8(3):239-53. doi: 10.3758/cabn.8.3.239.

Abstract

According to the processing-efficiency hypothesis (Eysenck, Derakshan, Santos, & Calvo, 2007), anxious individuals are thought to require greater activation of brain systems supporting cognitive control (e.g.,dorsolateral prefrontal cortex; DLPFC) in order to maintain equivalent performance to nonanxious subjects. A recent theory of cognitive control (Braver, Gray, & Burgess, 2007) has proposed that reduced cognitive efficiency might occur as a result of changes in the temporal dynamics of DLPFC recruitment. In this study, we used a mixed blocked/ event-related fMRI design to track transient and sustained activity in DLPFC while high- and low-anxious participants performed a working memory task. The task was performed after the participants viewed videos designed to induce neutral or anxiety-related moods. After the neutral video, the high-anxious participants had reduced sustained but increased transient activation in working memory areas, in comparison with low-anxious participants. The high-anxious group also showed extensive reductions in sustained activation of "default-network" areas (possible deactivation). After the negative video,the low-anxiety group shifted their activation dynamics in cognitive control regions to resemble those of the high-anxious group. These results suggest that reduced cognitive control in anxiety might be due to a transient, rather than sustained, pattern of working memory recruitment. Supplementary information for this study may be found at www.psychonomic.org/archive.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Affect / physiology*
  • Analysis of Variance
  • Anxiety / physiopathology
  • Anxiety / psychology*
  • Attention / physiology
  • Cognition / physiology
  • Efficiency / physiology*
  • Evoked Potentials / physiology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory, Short-Term / physiology*
  • Prefrontal Cortex / physiology*
  • Reference Values
  • Sex Factors