Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction

Claire C A Cariou; Guy J Clarkson; Michael Shipman

doi:10.1021/jo801664g

Rapid synthesis of 1,3,4,4-tetrasubstituted beta-lactams from methyleneaziridines using a four-component reaction

J Org Chem. 2008 Dec 19;73(24):9762-4. doi: 10.1021/jo801664g.

Authors

Claire C A Cariou¹, Guy J Clarkson, Michael Shipman

Affiliation

¹ Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

PMID: 18808185
DOI: 10.1021/jo801664g

Abstract

2-Methyleneaziridines can be transformed into a variety of 1,3,4,4-tetrasubstituted beta-lactams in moderate to good yields (46-63%) via a "one-pot" process that brings together four components with the formation of three new intermolecular carbon-carbon bonds.