Abstract
The first total synthesis of a thioglycoside analogue of KRN7000, a potential immunostimulant, is described. Two key intermediates are alpha-galactosyl thiol 4 and phytosphingosine derivative 5, which were both prepared from D-galactose.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / chemical synthesis*
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Adjuvants, Immunologic / chemistry
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Galactose / chemistry
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Galactosylceramides / chemical synthesis*
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Galactosylceramides / chemistry
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Molecular Structure
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Sulfhydryl Compounds / chemistry
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Thioglycosides / chemistry*
Substances
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Adjuvants, Immunologic
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Galactosylceramides
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Sulfhydryl Compounds
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Thioglycosides
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KRN 7000
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Galactose