Primary cutaneous B-cell lymphoma in a child

Fetal Pediatr Pathol. 2008;27(4-5):206-14. doi: 10.1080/15513810802319442.

Abstract

Primary cutaneous B-cell lymphoma is a B-cell lymphoma of the skin with no evidence of extracutaneous involvement at the time of diagnosis. In this report, we describe an 8-year-old boy who presented with a firm, alopecic, skin-colored, smooth nodule over the right frontal scalp. Histological examination revealed a mid-to deep-dermal mononuclear lesion. Immunohistochemical staining revealed a B-cell population that was CD10(+), CD5(-), CD21(+), and bcl2(-). This pattern of reactivity is characteristic of primary cutaneous B-cell lymphoma of follicle-center subtype. To the best of our knowledge, this is the first report of this type of cutaneous lymphoma in a child.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD19 / genetics
  • Antigens, CD20 / genetics
  • Child
  • Follow-Up Studies
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics
  • Genetic Markers
  • Humans
  • Immunoglobulin kappa-Chains / genetics
  • Immunohistochemistry
  • Lymphoma, B-Cell / genetics
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, B-Cell / surgery
  • Male
  • Neprilysin / genetics
  • Receptors, Complement 3d / genetics
  • Scalp / pathology
  • Scalp / surgery
  • Skin Neoplasms / genetics
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery
  • Time Factors
  • Treatment Outcome

Substances

  • Antigens, CD19
  • Antigens, CD20
  • Genetic Markers
  • Immunoglobulin kappa-Chains
  • Receptors, Complement 3d
  • Neprilysin