Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24

ChemMedChem. 2008 Oct;3(10):1525-9. doi: 10.1002/cmdc.200800188.
No abstract available

MeSH terms

  • Arginine / chemistry*
  • Crystallography, X-Ray
  • Drug Design
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / chemistry*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / pharmacology
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Arginine
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1