Abstract
Livers from hypophysectomized rats had low levels of glyceraldehyde 3-phosphate dehydrogenase mRNA. Administration of L-triiodothyronine increased these levels over 20-fold. The peak response was seen 72 h after hormone administration. A half-maximal response was obtained with 5 micrograms of T3 per 100 g of body weight. Thus the expression of hepatic glyceraldehyde 3-phosphate dehydrogenase appears to be regulated by thyroid hormone.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Blotting, Northern
-
Dose-Response Relationship, Drug
-
Gene Expression Regulation / drug effects*
-
Glyceraldehyde-3-Phosphate Dehydrogenases / genetics*
-
Kinetics
-
Liver / enzymology*
-
Male
-
Peptide Fragments / genetics*
-
RNA, Messenger / metabolism*
-
Rats
-
Rats, Inbred Strains
-
Triiodothyronine / pharmacology*
Substances
-
Peptide Fragments
-
RNA, Messenger
-
Triiodothyronine
-
glyceraldehyde 3-phosphate dehydrogenase (304-313)
-
Glyceraldehyde-3-Phosphate Dehydrogenases