Thyroid hormone increases glyceraldehyde 3-phosphate dehydrogenase gene expression in rat liver

FEBS Lett. 1991 Aug 19;288(1-2):21-2. doi: 10.1016/0014-5793(91)80993-d.

Abstract

Livers from hypophysectomized rats had low levels of glyceraldehyde 3-phosphate dehydrogenase mRNA. Administration of L-triiodothyronine increased these levels over 20-fold. The peak response was seen 72 h after hormone administration. A half-maximal response was obtained with 5 micrograms of T3 per 100 g of body weight. Thus the expression of hepatic glyceraldehyde 3-phosphate dehydrogenase appears to be regulated by thyroid hormone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Northern
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation / drug effects*
  • Glyceraldehyde-3-Phosphate Dehydrogenases / genetics*
  • Kinetics
  • Liver / enzymology*
  • Male
  • Peptide Fragments / genetics*
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Triiodothyronine / pharmacology*

Substances

  • Peptide Fragments
  • RNA, Messenger
  • Triiodothyronine
  • glyceraldehyde 3-phosphate dehydrogenase (304-313)
  • Glyceraldehyde-3-Phosphate Dehydrogenases