4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as potential pharmacological agents

Jerzy Kossakowski; Anna Bielenica; Barbara Mirosław; Anna E Kozioł; Izabela Dybała; Marta Struga

doi:10.3390/molecules13081570

4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as potential pharmacological agents

Molecules. 2008 Aug 6;13(8):1570-83. doi: 10.3390/molecules13081570.

Authors

Jerzy Kossakowski¹, Anna Bielenica, Barbara Mirosław, Anna E Kozioł, Izabela Dybała, Marta Struga

Affiliation

¹ Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland.

Abstract

A series of twenty six arylpiperazine and aminoalkanol derivatives of 4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione have been prepared. The synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.

MeSH terms

Alcohols / chemistry
Alcohols / pharmacology*
Alkanes / chemistry
Alkanes / pharmacology
Anti-HIV Agents / chemistry*
Anti-HIV Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Humans
Piperazines / chemistry
Piperazines / pharmacology*
Structure-Activity Relationship

Substances

Alcohols
Alkanes
Anti-HIV Agents
Piperazines
undecane