Background: This short report presents the case of a man with chronic anergy and mild depressive symptoms probably due to obstructive sleep apnea (OAS).
Method: The patient was treated with continuous positive airway pressure (CPAP).
Result: He developed a first manic episode at an atypical age simultaneously with the beginning of treatment.
Discussion: Several possible connections between affective syndromes, OAS, and CPAP treatment are proposed and discussed relating to current literature.