The use of a mandibular modular endoprosthesis after segmental resection of part of the body of the mandible was studied. This preliminary study was carried out on four pigs and four monkeys. The devices were made of a titanium alloy and were cemented in the prepared medullary spaces with polymethylmetacrylate cement. The prosthesis failed in one pig, but in the other animals the prostheses were stable and firmly fixed to the stumps after 3 months. It was concluded that the endoprosthesis has potential in reconstructive surgery of the mandible, but that further studies are necessary to substantiate this claim. Pigs are not suitable for further studies as the medullary space is too large and filled with fat. They are also too big to handle and the variations in size and shape of the mandibles precludes the use of a modular system.