Asymmetric hydrogenation of cyclic imines with an ionic Cp*Rh(III) catalyst

J Am Chem Soc. 2008 Oct 8;130(40):13208-9. doi: 10.1021/ja8050958. Epub 2008 Sep 11.

Abstract

When associated with a noncoordinating bulky counteranion, a cationic Cp*Rh(III)-diamine catalyst displayed excellent enantioselectivities in asymmetric hydrogenation of cyclic imines, affording bioactive tetrahydroisoquinolines and tetrahydro-beta-carbolines frequently with 99% ee's.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Catalysis
  • Cyclization
  • Hydrogenation
  • Imines / chemistry*
  • Ions / chemistry
  • Molecular Structure
  • Ruthenium Compounds / chemistry*
  • Stereoisomerism

Substances

  • Amines
  • Imines
  • Ions
  • Ruthenium Compounds