Abstract
In this issue of Cell Host & Microbe, OhAinle et al., 2008 report that APOBEC3H, a potent innate retroviral restriction factor in primates, lost its function twice independently during recent evolution in humans, stressing an ever present trade-off between benefit and cost of protection against pathogens.
MeSH terms
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Aminohydrolases
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Animals
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Anti-Retroviral Agents / metabolism*
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Cytosine Deaminase / genetics*
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Cytosine Deaminase / metabolism*
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Evolution, Molecular*
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Host-Parasite Interactions*
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Humans
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Primates / genetics
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Primates / metabolism
Substances
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Anti-Retroviral Agents
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APOBEC3H protein, human
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Aminohydrolases
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Cytosine Deaminase