Antiphospholipid syndrome (Hughes syndrome) is an autoimmune disorder with production of antibodies against phospholipids and phospholipid binding peptides in human organism, that is associated with thrombotic events. Venous and/or arterial tromboembolism and recurrent pregnancy loss at women are the most frequently observed clinical manifestations. Neurological symptoms are common and they can often mime multiple sclerosis. That is why antiphospholipid antibodies must be concerned in differential diagnostics of multiple sclerosis, particularly with the atypical course and clinical pattern.