Programmed regulation of conformational switching in diagnostic biomolecular automata using error control molecules

Miki Hirabayashi; Hirotada Ohashi; Tai Kubo

doi:10.1093/nass/nrn347

Programmed regulation of conformational switching in diagnostic biomolecular automata using error control molecules

Nucleic Acids Symp Ser (Oxf). 2008:(52):687-8. doi: 10.1093/nass/nrn347.

Authors

Miki Hirabayashi¹, Hirotada Ohashi, Tai Kubo

Affiliation

¹ Department of Quantum Engineering and Systems Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan. miki@crimson.q.t.u-tokyo.ac.jp

PMID: 18776566
DOI: 10.1093/nass/nrn347

Abstract

We aim to present novel biomolecular automata for transcriptome diagnosis. We already proposed several biomolecular probes for the prediction of oral squamous cell carcinoma as a model case and evaluated the system noise and sensitivity. Here we introduce an error control element and discuss the specificity of the system.

MeSH terms

Aptamers, Nucleotide / chemistry*
Carcinoma, Squamous Cell / diagnosis
Carcinoma, Squamous Cell / genetics*
Fluorescent Dyes / chemistry
Gene Expression Regulation
Humans
Mouth Neoplasms / diagnosis
Mouth Neoplasms / genetics*
Nucleic Acid Conformation
Oligonucleotide Probes / chemistry*
RNA, Messenger / analysis*
Rosaniline Dyes / chemistry
Sensitivity and Specificity
Transcription, Genetic*

Substances

Aptamers, Nucleotide
Fluorescent Dyes
Oligonucleotide Probes
RNA, Messenger
Rosaniline Dyes
malachite green