Synthesis and biological evaluation of 5''-iodoneplanocin A and its analogues

Nucleic Acids Symp Ser (Oxf). 2008:(52):653-4. doi: 10.1093/nass/nrn330.

Abstract

5''-Iodoneplanocin A was enantiopurely synthesized as potential antiviral and antitumor agents starting from D-ribose using an addition-iodination-elimination reaction, a RCM reaction and an oxidative rearrangement.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Adenosine / chemistry
  • Adenosine / pharmacology
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Purine Nucleosides / chemical synthesis
  • Purine Nucleosides / chemistry
  • Purine Nucleosides / pharmacology

Substances

  • 5''-iodoneplanocin A
  • Antiviral Agents
  • Purine Nucleosides
  • Adenosine