New and efficient synthesis of nucleoside polyphosphates and nucleoside monophosphate sugars

Svenja Warnecke; Chris Meier

doi:10.1093/nass/nrn295

New and efficient synthesis of nucleoside polyphosphates and nucleoside monophosphate sugars

Nucleic Acids Symp Ser (Oxf). 2008:(52):583-4. doi: 10.1093/nass/nrn295.

Authors

Svenja Warnecke¹, Chris Meier

Affiliation

¹ Organic Chemistry, Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.

PMID: 18776514
DOI: 10.1093/nass/nrn295

Abstract

A new and efficient method for the synthesis of nucleoside di- and triphosphates, dinucleoside tetraphosphates and nucleoside monophosphate sugars is described. This new route is based on cycloSal-nucleosyl-phosphate triesters as active ester that underlie fast conversion to the corresponding products.

MeSH terms

Biochemistry / methods
Dinucleoside Phosphates / chemical synthesis
Dinucleoside Phosphates / chemistry
Nucleotides / chemical synthesis*
Nucleotides / chemistry
Nucleotides, Cyclic / chemical synthesis*
Nucleotides, Cyclic / chemistry
Polyphosphates / chemistry*

Substances

Dinucleoside Phosphates
Nucleotides
Nucleotides, Cyclic
Polyphosphates
nucleoside monophosphate sugars