Design and synthesis of peptide-oligonucleotide conjugates as potential artificial ribonucleases

Nucleic Acids Symp Ser (Oxf). 2008:(52):529-30. doi: 10.1093/nass/nrn268.

Abstract

A series of peptide-oligonucleotide conjugates was synthesized. The peptide fragment was attached to the middle part of DNA sequence. For this purpose the new amidophosphite dC with linker at C5-position was synthesized.

MeSH terms

  • Oligodeoxyribonucleotides / chemical synthesis*
  • Oligodeoxyribonucleotides / chemistry
  • Organophosphorus Compounds / chemical synthesis
  • Organophosphorus Compounds / chemistry
  • Peptides / chemistry*
  • Phosphites / chemical synthesis
  • Phosphites / chemistry
  • Ribonucleases / chemical synthesis*
  • Ribonucleases / chemistry

Substances

  • Oligodeoxyribonucleotides
  • Organophosphorus Compounds
  • Peptides
  • Phosphites
  • phosphoramidite
  • Ribonucleases