A new linker group for functionalization of nucleic acids

Nucleic Acids Symp Ser (Oxf). 2008:(52):385-6. doi: 10.1093/nass/nrn196.

Abstract

A new linker bearing two orthogonal precursor groups - an amino group for the reaction with electrophilic agents, and also a terminal triple bond for the reaction with an aliphatic azido group (1,3-dipolar cycloaddition reaction) for the introduction of the different residues into nucleosides is designed and synthesized. 5'-Triphosphates of various nucleosides bearing proposed linker group have been obtained.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / chemical synthesis
  • Acetamides / chemistry
  • Deoxycytosine Nucleotides / chemistry
  • Deoxyribonucleosides / chemistry*
  • Deoxyribonucleotides / chemical synthesis
  • Deoxyribonucleotides / chemistry
  • Dideoxynucleosides / chemistry
  • Ethers / chemical synthesis
  • Ethers / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Phthalimides / chemical synthesis
  • Phthalimides / chemistry*

Substances

  • Acetamides
  • Deoxycytosine Nucleotides
  • Deoxyribonucleosides
  • Deoxyribonucleotides
  • Dideoxynucleosides
  • Ethers
  • N-3-phthalimidopropyl progargyl ether
  • Phthalimides
  • propynyloxypropyl trifluoroacetamide
  • 2'-deoxycytidine 5'-triphosphate