Abstract
A new linker bearing two orthogonal precursor groups - an amino group for the reaction with electrophilic agents, and also a terminal triple bond for the reaction with an aliphatic azido group (1,3-dipolar cycloaddition reaction) for the introduction of the different residues into nucleosides is designed and synthesized. 5'-Triphosphates of various nucleosides bearing proposed linker group have been obtained.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / chemical synthesis
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Acetamides / chemistry
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Deoxycytosine Nucleotides / chemistry
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Deoxyribonucleosides / chemistry*
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Deoxyribonucleotides / chemical synthesis
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Deoxyribonucleotides / chemistry
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Dideoxynucleosides / chemistry
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Ethers / chemical synthesis
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Ethers / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
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Phthalimides / chemical synthesis
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Phthalimides / chemistry*
Substances
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Acetamides
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Deoxycytosine Nucleotides
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Deoxyribonucleosides
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Deoxyribonucleotides
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Dideoxynucleosides
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Ethers
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N-3-phthalimidopropyl progargyl ether
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Phthalimides
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propynyloxypropyl trifluoroacetamide
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2'-deoxycytidine 5'-triphosphate