Chiral phosphonate internucleotide linkage: a promising modification for chimeric oligonucleotides?

Radek Liboska; Magdalena Petrová; Radek Pohl; Milos Budesínsky; Vladimíra Hurychová; Ivan Rosenberg

doi:10.1093/nass/nrn160

Chiral phosphonate internucleotide linkage: a promising modification for chimeric oligonucleotides?

Nucleic Acids Symp Ser (Oxf). 2008:(52):317-8. doi: 10.1093/nass/nrn160.

Authors

Radek Liboska¹, Magdalena Petrová, Radek Pohl, Milos Budesínsky, Vladimíra Hurychová, Ivan Rosenberg

Affiliation

¹ Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague, Czech Republic.

PMID: 18776381
DOI: 10.1093/nass/nrn160

Abstract

We have synthesized two different groups of oligonucleotides containing chiral isopolar nonisosteric phosphonate internucleotide linkages, and studied their properties in combination with natural phosphodiester ones. The improved synthetic procedures for the monomers preparation are also reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry
Endoribonucleases / chemistry
Isomerism
Oligodeoxyribonucleotides / chemical synthesis
Oligodeoxyribonucleotides / chemistry*
Organophosphonates / chemistry*
RNA / chemistry

Substances

Oligodeoxyribonucleotides
Organophosphonates
RNA
DNA
Endoribonucleases
2-5A-dependent ribonuclease