Abstract
This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aging / metabolism
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Animals
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Cell Differentiation / physiology
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Cell Line
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Cells, Cultured
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Female
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Follicle Stimulating Hormone / pharmacology*
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Gene Expression Regulation / drug effects*
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Gene Expression Regulation / physiology
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Genes, Wilms Tumor / physiology*
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Granulosa Cells / cytology
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Granulosa Cells / physiology
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Mice
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Models, Animal
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Nerve Growth Factor / pharmacology*
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Ovarian Follicle / drug effects
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Ovarian Follicle / growth & development
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Ovarian Follicle / metabolism
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Ovary / cytology
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Ovary / drug effects
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Ovary / metabolism*
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WT1 Proteins / genetics
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WT1 Proteins / metabolism*
Substances
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WT1 Proteins
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Follicle Stimulating Hormone
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Nerve Growth Factor