Fluid dynamics of nodal flow and left-right patterning in development

Dev Dyn. 2008 Dec;237(12):3477-90. doi: 10.1002/dvdy.21672.

Abstract

The manner in which the nodal flow determines the breaking of left-right symmetry during development is a beautiful example of the application of fluid dynamics to developmental biology. Detailed understanding of this crucial developmental process has greatly advanced by the transfer of ideas between these two disciplines. In this article, we review our and others' work on applying fluid dynamics and dynamical systems to the problem of left-right symmetry breaking in vertebrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Fluids / metabolism*
  • Body Patterning*
  • Computer Simulation
  • Embryo, Mammalian / embryology
  • Embryo, Nonmammalian / embryology
  • Models, Biological